Cart
sales@molnova.com
E-4031 dihydrochloride
CAS No. 113559-13-0
E-4031 dihydrochloride( E4031 )
Catalog No. M10476 CAS No. 113559-13-0
E-4031 is a class III antiarrhythmic agent that binds to Kv11.1 (hERG) and blocks the rapid delayed-rectifier K+ current (IKr).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 34 | In Stock |
|
| 5MG | 55 | In Stock |
|
| 10MG | 87 | In Stock |
|
| 25MG | 206 | In Stock |
|
| 50MG | 371 | In Stock |
|
| 100MG | 552 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameE-4031 dihydrochloride
-
NoteResearch use only, not for human use.
-
Brief DescriptionE-4031 is a class III antiarrhythmic agent that binds to Kv11.1 (hERG) and blocks the rapid delayed-rectifier K+ current (IKr).
-
DescriptionE-4031 is a class III antiarrhythmic agent that binds to Kv11.1 (hERG) and blocks the rapid delayed-rectifier K+ current (IKr), reversibly prolongs action potential duration in guinea pig papillary muscle and isolated ventricular myocytes, without affecting Na+ or Ca2+ inward currents.Heart Arrhythmia Phase 2 Clinical.
-
In Vitro——
-
In Vivo——
-
SynonymsE4031
-
PathwayCell Cycle/DNA Damage
-
TargetPotassium Channel
-
RecptorPotassium Channel
-
Research AreaCardiovascular Disease
-
IndicationHeart Arrhythmia
Chemical Information
-
CAS Number113559-13-0
-
Formula Weight474.441
-
Molecular FormulaC21H29Cl2N3O3S
-
Purity>98% (HPLC)
-
SolubilityH2O : ≥ 50 mg/mL105.39 mM
-
SMILESCC1=NC(=CC=C1)CCN2CCC(CC2)C(=O)C3=CC=C(C=C3)NS(=O)(=O)C.Cl.Cl
-
Chemical Name1-[2-(6-methyl-2pyridyl)ethyl]-4-(4-methylsulfonyl aminobenzoyl)piperidine dihydrochloride
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Katoh H, et al. J Pharmacol Exp Ther. 1990 Jun;253(3):1077-82.
2. Sano T, et al. Br J Pharmacol. 1990 Mar;99(3):577-81.
3. Lynch JJ Jr, et al. J Cardiovasc Pharmacol. 1990 May;15(5):764-75.
4. Smith JL, et al. Am J Physiol Cell Physiol. 2013 Nov 1;305(9):C919-30.
molnova catalog
related products
-
BMS-204352
A potent and effective calcium-sensitive opener of maxi-K potassium channels (maxi-K) with EC50 of 392 nM at -48.4 mV in HEK293 isolated outside-out membrane patches.
-
Atpenin A5
Atpenin A5 is a potent and highly specific?complex II?inhibitor (IC50?~10 nM). Atpenin A5 is also an effective?mKATP?channel?agonist and cardioprotective agent.
-
Dofetilide
Dofetilide is a selective potassium channel ((hERG)) blocker, used as a Class III antiarrhythmic drug
